Association of the Asp312Asn and Lys751 Gln polymorphisms in the XPD gene with the risk of non-Hodgkin's lymphoma:evidence from a meta-analysis

作     者：Shen Chen Jin-Hong Zhu Fang Wang Shao-Yi Huang Wen-Qiong Xue Zhuo Cui Jing He Wei-Hua Jia 

作者机构：State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineDepartment of Experimental ResearchSun Yat-sen University Cancer Center Molecular Epidemiology Lab and Laboratory MedicineHarbin Medical University Cancer Hospital Department of StatisticsUniversity of California 

出 版 物：《Chinese Journal of Cancer》 (Chinese Journal of Cancer)

年 卷 期：2015年第34卷第3期

页      面：108-114页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from the National Science Fund for Distinguished Young Scholars(No.81325018) the key project for International Cooperation and Exchange of the National Natural Science Foundation of China(No.81220108022) Special Financial Grant from the China Postdoctoral Science Foundation(No.2014 T70836) 

主　　题：多态性 淋巴瘤 D基因 风险 关联 DNA修复基因 金 证据 

摘      要：Polymorphisms in DNA repair genes may alter DNA repair capacity and,consequently,lead to genetic instability and *** studies have investigated the association of the Asp312 Asn and Lys751 Gln polymorphisms in the xeroderma pigmentosum complementation group D {XPD) gene with the risk of non-Hodgkin s lymphoma(NHL),but the conclusions have been ***,we performed this meta-analysis to more precisely estimate these relationships.A systematic literature search was performed using the PubMed,Embase,and Chinese Biomedical(CBM) ***,6 studies of Asp312 Asn,comprising 3,095 cases and 3,306 controls,and 7studies of Lys751 Gln,consisting of 3,249 cases and 3,676 controls,were *** odds ratios(ORs) and 95%confidence intervals(CIs) were calculated to assess the strength of each ***,no association was observed between the Asp312 Asn polymorphism and NHL risk(homozygous:OR = 1.11,95%CI = 0.94-1.32;heterozygous:OR = 1.00,95%CI = 0.89-1.11;recessive:OR = 1.12,95%CI = 0.95-1.31;dominant:OR = 1.02,95%CI = 0.92-1.13;and allele comparison:OR = 1.04,95%CI = 0.96-1.12) or between the Lys751 Gln polymorphism and NHL risk(homozygous:OR = 0.97,95%CI = 0.83-1.15;heterozygous:OR = 0.96,95%CI = 0.86-1.06;recessive:OR = 1.00,95%CI = 0.86-1.16;dominant:OR = 0.96,95%CI = 0.87-1.06;and allele comparison:OR = 0.98,95%CI = 0.91-1.05).Furthermore,subgroup analyses did not reveal any association between these polymorphisms and ethnicity,the source of the controls,or the NHL *** results indicated that neither the Asp312 Asn nor Lys751 Gln XPD polymorphism was related to NHL *** and well-designed prospective studies are required to confirm this finding.