Common stemness regulators of embryonic and cancer stem cells

作     者：Christiana Hadjimichael Konstantina Chanoumidou Natalia Papadopoulou Panagiota Arampatzi Joseph Papamatheakis Androniki Kretsovali 

作者机构：Department of Biology University of Crete Institute of Molecular Biology and Biote- chnology Foundation for Research and Technology Hellas(FORTH) Department of Molecular Biology and Genetics Democritus University of Thrace 

出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)

年 卷 期：2015年第7卷第9期

页      面：1150-1184页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学] 

基　　金：Supported by ESPA "Umbistem" 11ΣΥΝ_10_668 

主　　题：Embryonic stem cells Cancer stem cells Pluripotenc 

摘      要：Pluripotency of embryonic stem cells(ESCs) and induced pluripotent stem cells is regulated by a well characterized gene transcription circuitry. The circuitry is assembled by ESC specific transcription factors, signal trans-ducing molecules and epigenetic regulators. Growing understanding of stem-like cells, albeit of more complex phenotypes, present in tumors(cancer stem cells), provides a common conceptual and research frame-work for basic and applied stem cell biology. In this review, we highlight current results on biomarkers, gene signatures, signaling pathways and epigenetic regulators that are common in embryonic and cancer stem cells. We discuss their role in determining the cell phenotype and finally, their potential use to design next generation biological and pharmaceutical approaches for regenerative medicine and cancer therapies.