THE PHARMACOKINETIC QUESTION OF TOPICAL NEURO-PROTECTIVE AGENTS: HOW DOES A TOPICALLY APPLIED DRUG PENETRATE TO THE BACK OF THE EYE?
THE PHARMACOKINETIC QUESTION OF TOPICAL NEURO-PROTECTIVE AGENTS: HOW DOES A TOPICALLY APPLIED DRUG PENETRATE TO THE BACK OF THE EYE?作者机构:Department of Ophthalmology Hadassah University HospitalDepartment of Pharmaceutics School of Pharmacy The Hebrew University of Jerusalem IsraelDepartment of Pharmaceutics School of Pharmacy The Hebrew University of Jerusalem Israel
出 版 物:《国际眼科杂志》 (International Eye Science)
年 卷 期:2003年第3卷第1期
页 面:93-94页
学科分类:1002[医学-临床医学] 100212[医学-眼科学] 10[医学]
摘 要:Purpose: To evaluate the efficiency and the route of topical bri-monidine penetration to the back of the eye. Methods: After single instillation of 50μ1 of 3H -radiolabeled Alphagan solution (0.2%) in the cul-de-sac of the right eye, three male albino rabbits (2-2.5 kg) were sacrificed at each time point (5, 15, 30 and 60 min). Both eyes were dissected. Eyes specimens of aque-