THE PHARMACOKINETIC QUESTION OF TOPICAL NEURO-PROTECTIVE AGENTS: HOW DOES A TOPICALLY APPLIED DRUG PENETRATE TO THE BACK OF THE EYE?

作     者：M.Abdulrazik S.Tamilvanan S.Benita 

作者机构：Department of Ophthalmology Hadassah University HospitalDepartment of Pharmaceutics School of Pharmacy The Hebrew University of Jerusalem IsraelDepartment of Pharmaceutics School of Pharmacy The Hebrew University of Jerusalem Israel 

出 版 物：《国际眼科杂志》 (International Eye Science)

年 卷 期：2003年第3卷第1期

页      面：93-94页

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

主　　题：神经保护剂 药物动力学 局部用药 眼合 药物释放 

摘      要：Purpose: To evaluate the efficiency and the route of topical bri-monidine penetration to the back of the eye. Methods: After single instillation of 50μ1 of 3H -radiolabeled Alphagan solution (0.2%) in the cul-de-sac of the right eye, three male albino rabbits (2-2.5 kg) were sacrificed at each time point (5, 15, 30 and 60 min). Both eyes were dissected. Eyes specimens of aque-