干眼的流行病学研究中评估患者自述的疾病分类

作     者：Nichols J.J. Mitchell G.L. Nichols K.K 齐翔云 

作者机构：Ohio State University 320 West 10th Avenue Columbus OH 43218-2342 United States 

出 版 物：《世界核心医学期刊文摘（眼科学分册）》 (Digest of the World Core Medical Journals:Ophthalmology)

年 卷 期：2005年第1卷第2期

页      面：32-33页

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

主　　题：疾病分类 患者自述 中评估 流行病学研究 接触镜 分类误差 可信限 组内相关系数 社会人口学特征 统计量 

摘      要：PURPOSE. To evaluate the reliability of self-reported dry eye disease status and patient-related predictors of misclassification in contact lens wearers. ME THODS. Patients completed the Contact Lens Dry Eye Questionnaire (CLDEQ) short form on two occ asions. Test-retest reliability of the CLDEQ composite score was determined usi ng the 95%limits of agreement (LoA) and an intraclass correlation coefficient ( ICC). The κstatistic was used to determine reliability of disease-classificati on-based CLDEQ composite score cutoff points. Predictors of misclassification w ere determined by multivariate logistic regression. RESULTS. The sample included 274 patients. The range of CLDEQ composite scores from both visits was -1.83 t o 4.50 and the mean difference between administrations was -0.05±0.75 (P=0.30) . The 95%LoA of the CLDEQ composite score were -1.51 to 1.42 and the ICC was 0 .61 (95%confidence interval CI: 0.53-0.68). Calculations using the lower lim it of the 95%CI showed that three administrations of the survey would be requir ed to obtain a more desirable ICC (0.70). The κstatistic for reliability of dry eye disease classification was 0.58 (95%CI: 0.48-0.67). Logistic regression s howed a significant interaction between gender (females) and younger age (P=0.02 ) in relation to misclassification of self-reported dry eye disease status. CON CLUSIONS. The reliability of selfreported dry eye disease classification in cont act lens wearers is moderate. In epidemiologic studies of factors associated wit h self-reported disease status, investigators may be well advised to consider u sing multiple administers of such outcome instruments and controlling for sociod emographic characteristics to maintain internal validity.