口服热带蕨类植物的皮质萃取物可降低紫外线引起的人类皮肤损伤
Oral Polypodium leucotomos extract decreases ultraviolet- induced damage of human skin出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)
年 卷 期：2005年第1卷第8期
页 面：4-5页
学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学]
主 题：人类皮肤 萃取物 紫外线损伤 皮肤红斑 肥大细胞 皮肤类型 红斑反应 朗罕细胞 防护剂 表皮细胞
摘 要：UV radiation induces damage to human skin. Protection of skin by an oral photoprotective agent would have substantial benefits. We investigated the photoprotective effect of oral administration of an extract of the natural antioxidant Polypodium leucotomos (PL). A total of 9 healthy participants of skin types II to III were exposed to varying doses of artificial UV radiation without and after oral administration of PL (7.5 mg/kg). At 24 hours after exposure the erythema reaction was assessed and paired biopsy specimens were obtained from PL- treated and untreated skin. A significant decrease in erythema was found in PL- treated skin (P .01). Histologically, PL- treated biopsy specimens showed less sunburn cells (P .05), cyclobutane pyrimidine dimers (P .001), proliferating epidermal cells (P .001), and dermal mast cell infiltration (P .05). A trend toward Langerhans cell preservation was seen. Oral administration of PL is an effective systemic chemophotoprotective agent leading to significant protection of skin against UV radiation.
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