One-pot Three-component Reaction for Efficient and Facile Synthesis of γ-Nitrocarbonyl Compounds Under Solvent-free Conditions
One-pot Three-component Reaction for Efficient and Facile Synthesis of γ-Nitrocarbonyl Compounds Under Solvent-free Conditions作者机构：Shcool of Chemistry and Chemical Engineering Liaoning Normal University Dalian 116029 P. R. China
出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)
年 卷 期：2015年第31卷第2期
页 面：208-211页
核心收录：
学科分类：081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学]
基 金：Supported by the National Natural Science Foundation of China(No.21403100) and the Doctoral Scientific Research Foun- dation of Liaoning Province China(No.20141100)
主 题：γ-Nitrocarbonyl compound Multicomponent reaction One-pot reaction Solvent free
摘 要：A simple and efficient protocol was established to synthesize γ-nitrocarbonyl compounds via three-component one-pot tandem condensation reaction of aldehydes, Meldrum＇s acid and nitroalkanes under solventfree conditions. The present method shows fascinating features such as using readily available starting materials, promoting the yields by inexpensive and mild organic base triethylamine, omiting the synthesis of Michael acceptor and avoiding the use of organic solvent. This strategy provides an easy alternative synthetic approach to the useful intermediate, γ-nitrocarbonyl compounds, with moderate to good yields.
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