Vindesine induces rhabdomyolysis in patients with acute lymphoblastic leukemia

作     者：Liu Limin Sun Yumei Si Yejun Lin Guoqiang Zhang Xingxia Zhao Guangsheng Zhang Yanming Wu Depei 

作者机构：Department of Hematology Huai'an Hospital Affiliated to Xuzhou Medical College and Huai'an Second People's Hospital Huai'an Jiangsu 223002 China First Affiliated Hospital of Soochow University Jiangsu Institute of Hematology Key Laboratory of Thrombosis and Hemostasis of Ministry of Health Suzhou Jiangsu 215006 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2014年第127卷第21期

页      面：3835-3836页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from the Network Hospital of Clinical Medicine Science and Technology Project, Jiangsu Science and Technology Department Haematology Academician Workstation of Huai'an City 

主　　题：vindesine acute lymphoblastic leukemia rhabdomyolysis 

摘      要：Rhabdomyolysis is a syndrome which involves myoglobin and other intracellular proteins and electrolytes that occurs from breakdown of skeletal muscleand leak into the circulation. The clinical symptoms of rhabdomyolysis include myalgia, tenderness on palpation, weakness, brown urine, fever, myoglobinuria, electrolyte imbalance, and acute renal failure. Rhabdomyolysis can be severe enough to be life threatening. The causes of rhabdomyolysis include alcohol, electrolyte imbalance （potassium, phosphorus, and magnesium depletion）, viral myositis, trauma, connective tissue diseases, drug reaction, toxication, exercise, metabolic diseases, seizures, and hereditary enzyme deficiencies. The exact mechanisms underlying rhabdomyolysis are not fully understood, but it is clear that muscle damage can be caused by direct muscle injury or metabolic inequalities between energy production and energy consumption.