Correlation between LIFG and Autonomic Activation during Stressful Tasks:A Functional Near-infrared Spectroscopy (fNIRS) Study

作     者：史洁 酒谷薰 冈本雅子 山口由衣 左焕琮 

作者机构：Department of NeurologyYuquan HospitalTsinghua University School of Medicine Department of NeurosurgeryDivision of Optical Brain EngineeringNihon University School of Medicine Collaboration Promotion DepartmentShimadzu Corporation Department of NeurosurgeryYuquan HospitalTsinghua University School of Medicine 

出 版 物：《Journal of Huazhong University of Science and Technology(Medical Sciences)》 (华中科技大学学报（医学英德文版）)

年 卷 期：2014年第34卷第5期

页      面：663-671页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0836[工学-生物工程] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National High Technology Research and Development Program of China("863"Program,No.2012AA020905) the National Natural Science Foundation of China(No.81171143) the Project of International Cooperation and Exchanges of the National Natural Science Foundation of China(No.81161160570) the Zhou Dafu Medical Research Fund(No.202836019-03) 

主　　题：functional near-infrared spectroscopy mental arithmetic task verbal fluency task auto-nomic nervous system inferior frontal gyrus 

摘      要：It remains unclear whether language tasks in one＇s first （L1） or second （L2） language can cause stress responses and whether frontal, autonomic and behavioral responses to stressful tasks are correlated. In this study, we studied 22 Chinese subjects whose L2 was English and measured the cerebral blood oxygenation in their frontal lobe by using functional near-infrared spectroscopy （fNIRS） as par- ticipants engaged in a mental arithmetic task （MAT） and verbal fluency tasks （VFTs） in L1 （Chinese） and L2 （English）. To examine the activated cortical areas, we estimated the channel location based on Montreal Neurological Institute （MNI） standard brain space by using a-probabilistic estimation method. We evaluated heart rate （HR） changes to analyze autonomic nervous system （ANS） functioning. We found that the MAT and VFTs induced greater increases in HR than did the control （Ctrl） task. Further- more, subjects developed greater increases in HR in the MAT and VFTt~ than they did in the VFTL1. Compared with the Ctrl task, the MAT and both VFTLland VFTL2 produced robust and widespread bi- lateral activation of the frontal cortex. Interestingly, partial correlation analysis indicated that the activity in the left inferior frontal gyrus （LIFG） [Brodmarm＇s area （BA） 47] was consistently correlated with the increases in HR across the three tasks （MAT, VFTL2, and VFTL1）, after controlling for the performance data. The present results suggested that a VFT in L2 may be more stressful than in L1. The LIFG may affect the activation of the sympathetic system induced by stressful tasks, includin~ MATs and VFTs.