Solid Tumor Inhibitory and other Constituents of Casimiroa tetrameria

作     者：XU Ya-Ming Maria del C. Ramirez-Ahumada Frederick A. Valenote A. A. Leslie Gunatilaka 

作者机构：Southwest Center for Natural Products Research and Commercialization School of Natural Resources and the Environment The University of Arizona 250 E Valencia Road Tucson Arizona 85706-6800 USA Division of Hematology & Oncology Henry Ford Hospital Detroit Michigan 48202 USA 

出 版 物：《中国天然药物》 (CHINESE JOURNAL OF NATURAL MEDICINES)

年 卷 期：2011年第9卷第5期

页      面：334-337页

学科分类：0710[理学-生物学] 1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1005[医学-中医学] 1002[医学-临床医学] 0703[理学-化学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the US National Institutes of Health research grant CA092143 awarded by National Cancer Institute 

主　　题：Casimiroa tetrameria Rutaceae Solid tumor selectivity Flavonoids Zapotin Furanocoumarins N-benzoyltyramides 

摘      要：AIM:To isolate and characterize solid tumor inhibitory and other constituents from a bioactive extract of Casimiroa tetrameria((Rutaceae).METHODS:A crude extract of *** obtained from the US National Cancer Institute Natural Product Repository and found to exhibit selective toxicity to solid tumor cells was subjected bioactivity-guided fractionation involving solvent-solvent partitioning,gel filtration,and *** structures of all isolated compounds were elucidated by spectroscopic analysis(NMR and MS) and/or by comparison with the reported *** 1 and 4-9 were evaluated for their solid tumor selective ***:Nine metabolites,including a new furanocoumarin,5-methoxy-8-(4 -acetoxy-3 -methylbut-2-eny-loxy)-psoralen(1),and the previously known compounds 2-9 were *** these the flavonoid zapotin(6),and N-benzoyltyramide derivatives 7 and 8 were found to be the active ***:Zapotin(6) is the most potent constituent of *** with solid tumor selectivity.