Metabolic assessement of spleen infiltration by non-Hodgkin lymphoma using ^(18)F-FDG PET/CT:Preliminary clinical results

作     者：SUN Long PAN Weimin LUO Zuoming WEI Jihong ZHAO Long WU Hua 

作者机构：Minnan PET Center and Department of Nuclear Medicine No.1 Hospital of Xiamen Fujian Medical University Xiamen 316003 China 

出 版 物：《Nuclear Science and Techniques》 (核技术（英文）)

年 卷 期：2009年第20卷第4期

页      面：235-242页

核心收录：

学科分类：07[理学] 0807[工学-动力工程及工程热物理] 0827[工学-核科学与技术] 0703[理学-化学] 070202[理学-粒子物理与原子核物理] 0702[理学-物理学] 0801[工学-力学（可授工学、理学学位）] 

基　　金：Supported by Commission of Science and Technology of Xiamen City (Grant No.3502720077056) 

主　　题：SUV ^18F-FDG PET/CT 能级 原子核物理学 

摘      要：18F-FDG PET/CT was used for evaluation of spleen infiltration in patients with B-cell non-Hodgkin lymphoma(NHL).Five patients with histological diagnosed B-cell NHL underwent1 8F-FDG PET/CT *** integrated PET/CT image,spleen infiltration was considered when PET images revealed a discrete margin of solid splenic masses or diffuse lesion of spleen with higher maximum standardized uptake value(SUV) greater than those of normal liver *** images demonstrating a positive splenic index(480 mL)or focal hypodensities were classified as positive for spleen *** the patients underwent systemic ***1 8F-FDG PET and CT results were compared with final *** patients had spleen infiltration originating from B-cell NHL at final *** diagnoses,which were confirmed by clinical and CT(n=3) or1 8F-FDG PET/CT(n=1) follow-up in 4 patients and biopsy of 1 *** integrated PET/CT image,1 8F-FDG PET was true-positive in all 5 patients with spleen *** was true-positive in 4 of the 5 patients with spleen infiltration and false-negative in 1 patients (spleen infiltration without morphology changes).The accuracies of1 8F-FDG PET and CT for evaluating the spleen infiltration were 100% and 80% at staging,*** preliminary results suggested metabolic imaging of1 8F-FDG PET/CT may be helpful in the diagnosis of spleen infiltration in B-cell NHL *** patients may benefit from1 8F-FDG PET/CT in diagnosis,when spleen infiltration without morphology changes,which may not be diagnosed exactly by conventional image.