饮食补充ω-3脂肪酸对慢性心力衰竭患者内皮依赖性血管舒张功能的影响

作     者：Morgan D.R. Dixon L.J. Hanratty C.G. 柴大军 

作者机构：Department of Therapeutics and Pharmacology Queen's University Belfast Belfast United Kingdom Dr. 

出 版 物：《世界核心医学期刊文摘（心脏病学分册）》 (Digest of the World Core Medical Journals(Cardiology))

年 卷 期：2006年第2卷第6期

页      面：41-42页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：内皮依赖性血管舒张功能 慢性心力衰竭患者 ω-3脂肪酸 饮食补充 乙酰胆碱(ACH) 慢性心力衰竭(CHF) L-精氨酸甲酯 药物治疗 血管紧张素Ⅱ 平均年龄 

摘      要：We investigated the effects of omega- 3 fatty acids administration on endothelium- dependent vasodilation in patients 65 years old who received treatment for chronic heart failure(CHF). Twenty patients(mean age 73 years; 15 men) with grade II and III CHF who were on maximal medical management were recruited. Patients were randomized in a double- blind, crossover fashion to 6 weeks of omega- 3 fatty acid(1.8 g ecosapentaenoic acid and 1.2 g docosahexaenoic acid) or olive oil. Forearm blood flow(FBF) responses to incremental doses of intra- arterial sodium nitroprusside, acetycholine(ACH), angiotensin- II, and Ng- nitro-l- arginine methyl ester were assessed by venous occlusion strain gauge plethysmography. The endothelium- dependent increase in FBF was greater in response in ACH infusion after omega- 3 fatty acid administration(7.9, 95% confidence interval [CI] 4.81 to 11.08 to 11.3, 95% CI 7.31 to 15.23 arbitrary units(p 0.05) compared with baseline(7.95, 95% CI 4.8 to 11.08 arbitrary units) and olive oil administration(7.27, 95% CI 4.66 to 9.88 arbitrary units)(p=NS for both). Neither omega- 3 fatty acid nor olive oil altered endothelium- independent vasodilation in response to infusion of sodium nitroprusside, nor did they influence vasoconstrictor responses to angiotensin- II or Ng- nitro- l- arginine methyl ester. Dietary omega- 3 fatty acid supplementation was accompanied by an increase in FBF response to ACH, which represents enhanced endothelium- dependent vasodilation in CHF. Further studies are warranted to assess the mechanism responsible for the beneficial actions of omega- 3 fatty acids in CHF.