Fuxin decoction attenuates doxorubicin-induced heart failure in rats via oxidizing suppression and regulating immune responses

作     者：Guo Yuhong Di Tingting Zhao Jingxia Xu Xiaolong Li Ping Huang Lijuan Liu Qingquan 

作者机构：Intensive Care UnitBeijing Hospital of Traditional Chinese MedicineAffiliated with Capital Medical University Beijing Institute of Traditional Chinese MedicineBeijing Hospital of Traditional Chinese MedicineAffiliated with Capital Medical University 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2018年第38卷第4期

页      面：579-584页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：grants from clinical-scientific research program of Capital Medical University(No.16JL74) Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support(No.ZYLX201611) 

主　　题：Fuxin decoction Doxorubicin Conges-tive heart failure Oxidizing suppression Immuneregulation 

摘      要：OBJECTIVE:To observe the effects of Fuxin decoction in rats with heart failure induced by doxorubicin ***:We employed a doxorubicin-induced heart failure model to investigate the effect of Fuxin *** were orally administered with Fuxin decoction from 10 to 40 mg/*** structure changes were assessed by histology,circulating levels of oxidative stress-related biomarkers and inflammatory cytokines were detected via enzyme-linked immunosorbent ***:Administration of Fuxin decoction improved the growth retardation in doxorubicin hydrochloride injection *** involvement was alleviated by Fuxin decoction,as well as changes of congestion systemic circulation in this rat ***,Fuxin decoction regulates immune responses and suppresses oxidation reaction in doxorubicin hydrochloride-induced ***:Fuxin decoction might be an interesting candidate for congestive heart failure.