Recent advances in the management of distal ulcerative colitis

作     者：Ioannis E Koutroubakis 

作者机构：Department of GastroenterologyUniversity Hospital Heraklion 

出 版 物：《World Journal of Gastrointestinal Pharmacology and Therapeutics》 (世界胃肠药理与治疗学杂志（英文版）（电子版）)

年 卷 期：2010年第1卷第2期

页      面：43-50页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Aminosalicylates Azathioprine Infliximab mesalazine Ulcerative colitis 

摘      要：The most frequent localization of ulcerative colitis(UC) is the distal *** treating patients with active distal UC,efficacy and targeting of the drug to the distal colon are key *** and rectal 5-aminosalicylic acid(5-ASA) preparations represent the first line therapy of mild-to-moderate distal UC for both induction and maintenance *** has been reported that many UC patients are not adherent to therapy and that noncompliant patients had a 5-fold risk of experiencing a *** findings led to the introduction of oncedaily oral regimens of 5-ASA as better therapeutic options in clinical practice due to improved *** formulations of mesalazine,including the multimatrix delivery system,and mesalazine granules,which allow once-daily administration,have been *** have been demonstrated to be efficacious in inducing and maintaining remission in mild-to-moderate distal UC in large clinical ***,existing data for distal UC are rather insufficient to make a comparison between new and classical 5-ASA *** seems that the new formulations are at least as effective as classical oral 5-ASA *** treatment options,in the case that 5-ASA therapy is not effective,include systemic corticosteroids,thiopurines(azathioprine or 6-mercaptopurine),cyclosporine,infliximab and *** combination of a prompt diagnostic work-up,a correct therapeutic approach and an appropriate follow-up schedule is important in the management of patients with distal *** approach can shorten the duration of symptoms,induce a prolonged remission,improve patient s quality of life,and optimize the use of health resources.