Protection effect of Xuanfudaizhetang on reflux esophagitis in rats

作     者：Bing Liang Zhong-Hua Liu Hai-Tao Wei Zhi Zhang Gong-Ning Shi 

作者机构：Department of Cardiothoracic SurgeryHuahe HospitalHenan University Medical CollegeHenan University 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2014年第7卷第4期

页      面：267-270页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by Project of Education Department in Henan Province No:12A320004 

主　　题：Xuanfudaizhetang Reflux esophagitis Esophageal mucosa PH value Treatment 

摘      要：Objective:To study protection effect of Xuanfudaizhetang on reflux esophagitis in ***:A total of 50 Wistar rats were randomly divided into groups A,B,C,D and E with 10 in *** esophagitis model in rats was established by incomplete helicobacter seam+lower esophagus *** rats were divided into 5 groups:group A as control group,group B as model group,group C with saline lavage treatment,group D with motilium treatment,group E with Xuanfudaizhetang lavage *** of esophageal,gastric mucosa and pH changes of rats were compared between ***:Weight gain in group D and E was significantly higher in than group C;the esophageal mucosa grades and esophagus tissue pathological morphology grades of group D and E were higher than that of group B and C with significant difference between groups(P0.05);pH of lower esophageal mucosa in group D and E increased significantly than that in the group B and C(P0.05),and the distal mucosal pH dropped significantly in the group B and C(P0.05).Conclusions:Xuanfudaizhetang can obviously improve the pH of lower esophageal mucosa in rats with reflux esophagitis,decrease pH value of gastric mucosal,thus improve esophageal mucosa pathological conditions to achieve therapeutic effect on reflux esophagitis.