Synthesis and biocompatibility of a biodegradable and functionalizable thermo-sensitive hydrogel

作     者：Mantosh K.Sinha Jin Gao Chelsea E.T.Stowell Yadong Wang 

作者机构：Department of Bioengineering and the McGowan Institute for Regenerative MedicineUniversity of PittsburghPittsburghPA 15219USA Department of SurgeryUniversity of PittsburghPittsburghPA 15260USA Department of Chemical and Petroleum EngineeringSwanson School of EngineeringUniversity of PittsburghPittsburghPA 15261USA Department of Mechanical Engineering and Materials ScienceUniversity of PittsburghPittsburghPA 15261USA Clinical Translational Science InstituteUniversity of Pittsburgh School of MedicinePittsburghPA 15261USA The McGowan Institute for Regenerative MedicineUniversity of Pittsburgh School of MedicinePittsburghPA 15261USA 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2015年第2卷第3期

页      面：177-185页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：This work was supported by the National Institutes of Health and Clinical and Translational Science Institute(NIH UL1TR000005) the National Science Foundation under grant no.1247842.The authors thank Dr Keewon Lee for helpful discussions on cell culture and fluorescence microscopy 

主　　题：biodegradable thermoresponsive hydrogel drug delivery materials synthesize 

摘      要：Injectable thermal gels are a useful tool for drug delivery and tissue ***,most thermal gels do not solidify rapidly at body temperature(37C).We addressed this by synthesizing a thermo-sensitive,rapidly biodegrading *** hydrogel,poly(ethylene glycol)-co-poly(propanol serinate hexamethylene urethane)(EPSHU),is an ABA block copolymer comprising A,methoxy poly ethylene glycol group and B,poly(propanol L-serinate hexamethylene urethane).EPSHU was characterized by gel permeation chromatography for molecular weight and 1H NMR and Fourier transformed infrared for *** studies measured the phase transition *** vitro degradation in cholesterol esterase and in Dulbecco’s phosphate buffered saline(DPBS)was tracked using the average molecular weight measured by gel permeation ***/DEAD and resazurin reduction assays performed on NIH 3T3 fibroblasts exposed to EPSHU extracts demonstrated no *** implantation into BALB/cJ mice indicated good biocompatibility in *** biodegradability and biocompatibility of EPSHU together make it a promising candidate for drug delivery applications that demand carrier gel degradation withinmonths.