Field cancerization in the colon:a role for aberrant DNA methylation?

作     者：Yanxin Luo Ming Yu William M.Grady 

作者机构：Department of Colorectal SurgeryThe Sixth Affiliated HospitalSun Yat-Sen UniversityGuangzhouP.R.China Gastrointestinal InstituteSun Yat-Sen UniversityGuangzhouP.R.China Clinical Research DivisionFred Hutchinson Cancer Research CenterSeattleWAUSA Department of MedicineUniversity of Washington School of MedicineSeattleWAUSA 

出 版 物：《Gastroenterology Report》 (胃肠病学报道（英文）)

年 卷 期：2014年第2卷第1期

页      面：16-20页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This manuscript was supported by National Institutes of Health(NIH)National Cancer Institute(NCI)NIH awards RO1CA115513,P30CA15704,UO1CA152756,U54CA143862,and P01CA077852(WMG) Burroughs Wellcome Fund Translational Research Award for Clinician Scientist(WMG) 

主　　题：colorectal cancer field cancerization epigenetic alterations DNA methylation 

摘      要：Colorectal cancer is the third most common cancer worldwide and arises secondary to the progressive accumulation of genetic and epigenetic alterations in normal colon cells,which results in a polyp-to-cancer progression *** is known that individuals with a personal history of colon adenomas or cancer are at increased risk for metachronous colon *** explanation for this increased risk could be field cancerization,which is a phenomenon in which the histologically normal tissue in an organ is primed to undergo *** alterations appear to be promising markers for field *** this review,we discuss field cancerization in the colon and the data supporting the use of methylated DNA as a biomarker for this phenomenon.