Spatiotemporal alterations of presynaptic elements in the retina after high intraocular pressure

作     者：Jufang Huang Lihong Zhou Hui Wang Jia Luo Kun Xiong Leping Zeng Dan Chen 

作者机构：Department of Anatomy and NeurobiologyXiangya School of MedicineCentral South UniversityChangsha 410013Hunan ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2012年第7卷第16期

页      面：1234-1240页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 0905[农学-畜牧学] 09[农学] 071003[理学-生理学] 

基　　金：sponsored by the Ph.D.Programs Foundation of the Ministry of Education of China,No20090162110019 the Natural Science Foundation of Hunan Province,No. 10JJ4023 the Fundamental Research Funds for the Central Universities of China,No. 2011QNZT128 Graduate Scientific Research Innovation Projects of Hunan Province in 2011,No. CX2011B047 

主　　题：synaptophysin synapse-associated protein 102 synaptic plasticity elevated intraocular pressure retina neural regeneration 

摘      要：A rat model of acute high intraocular pressure was established by injecting saline into the anterior chamber of the left eye. Synaptophysin expression was increased in the inner plexiform layer at 2 hours following injury, and was widely distributed in the outer plexiform layer at 3-7 days, and then decreased to the normal level at 14 days. This suggests that expression of this presynaptic functional protein experienced spatiotemporal alterations after elevation of intraocular pressure. There was no significant change in the fluorescence intensity and distribution pattern for synapse-associated protein 102 following elevated intraocular pressure. Synapse-associated protein 102 immunoreactivity was confined to the outer plexiform layer, while synaptophysin immunoreactivity spread into the outer plexiform layer and the outer nuclear layer at 3 and 7 days following injury. These alterations in presynaptic elements were not accompanied by changes in postsynaptic components.