Toxicity and bio-distribution of carbon dots after single inhalation exposure in vivo

作     者：Yue Yang Xiangling Ren Zhenning Sun Changhui Fu Tianlong Liu Xianwei Meng Zili Wang 

作者机构：College of Animal Science and Technology Southwest University Chongqing 400716 China Laboratory of Controllable Preparation and Application of Nanomaterials CAS Key Laboratory of Cryogenics Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 China College of Veterinary Medicine China Agricultural University Beijing 100193 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2018年第29卷第6期

页      面：895-898页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070205[理学-凝聚态物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 070301[理学-无机化学] 0702[理学-物理学] 

基　　金：financial support from the National Natural Science Foundation of China (Nos. 61571426, 61671435, 31400854) National Hi-Tech. Research and Development Program of China (No. 2013AA032201) Beijing Natural Science Foundation (No. 4161003) 

主　　题：Carbon dots Toxicity Bio-distribution Inhalation Fluorescent intensity 

摘      要：Because of the advantages of excellent light stability, carbon dots（CDs） are considered to be a promising agent in the bio-marker application. Nevertheless, there are many unresolved issues with the toxicity of CDs in vitro and in vivo. In the study, CDs were synthesized by citric acid and ethylenediamine into deionized water, then the inhalation toxicity and bio-distribution of CDs in vivo were systematically assessed. The results showed that CDs caused animals death at higher dosages and induced injury in the lung and liver including inflammation and necrosis after single inhalation exposure at 5, 2 and 1 mg/kg dosages of the CDs. We also found that the injury increase with a dose-dependent and time-dependent manner. Fluorescent examination and TEM results showed that CDs mainly located at the lung and *** the fluorescent intensity increase with a time-dependent manner. This study provides a theoretical basis of the respiratory toxicity of CDs, and provides a basis for the use of CDs as a bio-marker.