Risk factors and clinical implication of superimposed Campylobacter jejuni infection in patients with underlying ulcerative colitis

作     者：Zubin Arora Saurabh Mukewar Xianrui Wu Bo Shen 

作者机构：Center for Inflammatory Bowel DiseasesDigestive Disease InstituteThe Cleveland Clinic FoundationClevelandOHUSA 

出 版 物：《Gastroenterology Report》 (胃肠病学报道（英文）)

年 卷 期：2016年第4卷第4期

页      面：287-292,I0001,I0002页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Ed Joey Story Endowed Chair 

主　　题：Campylobacter jejuni infection ulcerative colitis risk factors outcomes 

摘      要：Background and aims:Superimposed Campylobacter jejuni infection(CJI)has been described in patients with ulcerative colitis(UC).Its risk factors and impact on the disease course of UC are not *** aims were to evaluate the risk factors for CJI in UC patients and the impact of the bacterial infection on outcomes of ***:Out of a total of 918 UC patients tested,21(2.3%)of patients were found to be positive for CJI(the study group).The control group comprised 84 age-matched UC patients who had tested negative for *** factors for CJI and UC-related outcomes at 1 year after diagnosis of CJI were compared between the two ***:Ten patients(47.6%)with CJI required hospital admission at the time of diagnosis,including eight for the management of“UC flare.Treatment with antibiotics resulted in improvement in symptoms in 13 patients(61.9%).On multivariate analysis,hospital admission in the preceding year was found to be an independent risk factor for CJI[odds ratio(OR):3.9;95%confidence interval(CI):1.1–14.1]and there was a trend for chronic liver disease as a strong risk factor(OR:5.0;95%CI:0.9–28.3).At 1-year follow up,there was a trend for higher rates of UC-related colectomy(28.8% vs.14.3%;P=0.11),and mortality(9.5%vs.1.2%;P=0.096)in the study ***:Recent hospitalization within 1 year was found to be associated with increased risk for CJI in UC *** was a trend for worse clinical outcomes of UC with in patients with superimposed CJI,which was frequently associated with UC flare requiring hospital admission.