Synthesis and characterization of collagen/PLGA biodegradable skin scaffold fibers

作     者：Alireza Sadeghi-Avalshahr Samira Nokhasteh Amir Mahdi Molavi Mohammad Khorsand-Ghayeni Meysam Mahdavi-Shahri 

作者机构：Materials Research DepartmentIranian Academic Center for EducationCulture and Research(ACECR)Khorasan Razavi BranchMashhadIran 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2017年第4卷第5期

页      面：309-314页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1001[医学-基础医学(可授医学、理学学位)] 0805[工学-材料科学与工程（可授工学、理学学位）] 10[医学] 

基　　金：The authors wish to acknowledge the financial support of the Iranian Academic Center for Education Culture and Research(ACECR)(Grant No.2146-21) 

主　　题：tissue engineering composite scaffold biocompatibility skin cells 

摘      要：The aim of this study is to investigate the applicability of poly(lactic-co-glycolic acid)(PLGA)/collagen composite scaffold for skin tissue *** and collagen were dissolved in HFIP as a common solvent and fibrous scaffolds were prepared by electrospinning *** scaffolds were characterized by scanning electron microscopy(SEM),FTIR spectroscopy,mercury porosimetry,tensile strength,biocompatibility assays and *** and cell adhesion were tested for two cell line groups,human dermal fibroblast(HDF)and human keratinocyte(HaCat).SEM images showed appropriate cell adhesion to the scaffold for both cell *** assays indicated that the cell viability of HDF cells increased with time,but the number of HaCat cells decreased after 14 *** ultimate tensile strength was suitable for skin substitute application,but its elongation at break was rather *** successful clinical application of the PLGA/collagen scaffold,some properties especially mechanical strain needs to be improved.