Ultrasound assessment of left cardiac function in patients with gestational hypertension and its correlation with serum cytokine contents
Ultrasound assessment of left cardiac function in patients with gestational hypertension and its correlation with serum cytokine contents作者机构：Special Inspection DepartmentGuangyuan Central Hospital in Sichuan ProvinceGuangyuanSichuan Province628000
出 版 物：《Journal of Hainan Medical University》 (海南医学院学报（英文版）)
年 卷 期：2018年第24卷第4期
页 面：124-127页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Gestational hypertension Ultrasonic left cardiac function Endothelial function Inflammatory factor
摘 要：Objective: To investigate the ultrasound assessment of left cardiac function in patients with gestational hypertension and its correlation with serum cytokine contents. Methods: A total of 76 patients with gestational hypertension who were treated in Guangyuan Central Hospital between August 2015 and February 2017 were selected as gestational hypertension group, and 50 healthy pregnant women who received regular prenatal examination in Guangyuan Central Hospital during the same period were selected as normal control group. The differences in the ultrasonic left cardiac function parameter levels as well as serum contents of endothelial injury indexes and inflammatory factors were compared between the two groups of pregnant women. Pearson test was used to assess the correlation of ultrasonic left cardiac function parameter levels of gestational hypertension with serum endothelial injury index and inflammatory factor contents. Results: LAVmax, LVESV and LVEDV levels in gestational hypertension group were significantly higher than those in normal control group;serum endothelial injury indexes NO and PGE2 contents were lower than those of normal control group whereas ET-1 content was higher than that of normal control group;serum inflammatory factors IL-2, IFN-γ, IL-10, IL-13, IL-17 and IL-23 contents were significantly higher than those of normal control group. Correlation analysis showed that the ultrasonic left cardiac function parameter levels in patients with gestational hypertension were directly correlated with serum content of endothelial injury indexes and inflammatory factors. Conclusion: Ultrasonic left cardiac function parameter levels significantly change in patients with gestational hypertension, and the specific levels are directly correlated with the degree of endothelial injury and inflammatory response in the pregnant women.
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