Evaluation of Post-operative Anti-stress Response of Dexmedetomidine in Dogs

作     者：Guan Wei Feng Xiu-jing Zhang Liang-yu Luan Li Wang Jin-yu Tang Yue-shun Liu Tao Fan Hong-gang 

作者机构：Heilongjiang Key Laboratory for Animals and Comparative Medicine College of Veterinary Medicine Northeast Agricultural University College of Veterinary Medicine Northeast Agricultural University College of Veterinary Medicine Liaoning Medical University 

出 版 物：《Journal of Northeast Agricultural University(English Edition)》 (东北农业大学学报（英文版）)

年 卷 期：2018年第25卷第2期

页      面：27-32页

学科分类：090603[农学-临床兽医学] 09[农学] 0906[农学-兽医学] 

基　　金：Supported by China Postdoctoral Science Foundation of Heilongjiang Province(LBH-Q14018) the National Key Research and Development Program of China(2016YED0501008) "Academic Backbone"Project of Northeast Agricultural University(15XG18) 

主　　题：dog dexmedetomidine anti-stress 

摘      要：The stress response, caused by postoperative pain, may have adverse effects on physiological functions of bodies. And, it has been a research priority in veterinary anesthesia that is a method of minimizing the postoperative stress response. The paper aimed to explore the protective effect of dexmedetomidine on stress induced by surgical trauma by studying the effect of dexmedetomidine on the blood glucose, serum cortisol （Cor） and adrenocorticotropic hormone （ACTH） levels in the model of canine stress induced by surgical trauma. Therefore, 32 local healthy female dogs with similar physical conditions, aged from 11.3±2.4 months and meanbody mass （±SD） （7.7±2.2） kg, were randomly divided into four groups： control group DZ （10 min after administration of intramuscular injection of 2 mL normal saline）, group SQY （10 min before administration of intramuscular injection of 20 μg ？ kg-1 dexmedetomidine）, group SHY （10 min after administration of intramuscular injection of 20 μg ？ kg-1 dexmedetomidine） and group DLD （10 min after administration of intramuscular injection of 0.1 mL ？ kg-1 tilidine）. The corresponding drug was sucked out and diluted to 2 mL by saline. The four groups were all excised the uterus and ovaries and established surgical trauma stress model, then given the prescribed dose of the drug on the day of operation, the next day and the 3rd day. Besides, the dogs should be fasted during the days of drug administration. Blood samples were separated and taken to measure, blood glucose, serum Cor and ACTH concentration. The concentration of blood glucose was significantly lower in group SHY than that in group DZ on the day of surgery and the day after surgery （p〈0.05）, besides, it was not obviously different from other two groups. While, the concentration of Cor in group SHY had no significant differences from other three groups （p〉0.05） and was closer to the preoperative values; ACTH concentration in group SHY was significantly different from other three groups on the day of operation （p〈0.05）, and there existed significant difference （p〈0.05） with group DZ on the 2nd day after the operation. The results of analyses showed that 20 μg ？ kg-1dexmedetomidine could decrease the levels of Cor and ACTH in dog serum after operation, which played the role of anti-stress response stimulated by operations.