Value of transrectal ultrasonography for tumor node metastasis restaging in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy

作     者：Hai-Hua Peng Kai-Yun You Cheng-Tao Wang Rong Huang Hong-Bo Shan Jian-Hua Zhou Xiao-Qing Pei Yuan-Hong Gao Bi-Xiu Wen Meng-Zhong Liu 

作者机构：Department of Radiation OncologyFirst Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of RadiotherapySun Yat-sen University Cancer CenterState Key Laboratory of Oncology in Southern ChinaGuangzhouChina Department of Endoscopy and LaserSun Yat-sen University Cancer CenterState Key Laboratory of Oncology in Southern ChinaGuangzhouChina Department of UltrasonographySun Yat-sen University Cancer CenterState Key Laboratory of Oncology in Southern ChinaGuangzhouChina 

出 版 物：《Gastroenterology Report》 (胃肠病学报道（英文）)

年 卷 期：2013年第1卷第3期

页      面：186-192页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This study was supported by National Natural Science Funding of China(81071891,81172209) Guangdong Provincial Science&Technology Funding(2010B0807017,2010B031600090) 

主　　题：Rectal cancer neo-chemoradiotherapy(neo-CRT) transrectal ultrasonography(TRUS) TNM restaging 

摘      要：Objective:To explore the value of transrectal ultrasonography(TRUS)for tumor node metastasis(TNM)restaging for patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy(neo-CRT).Methods:One hundred and forty-nine patients with locally advanced rectal cancer(cT3-4 or cN+)who underwent TRUS after neo-CRT were retrospectively *** restaging was compared with the results of post-operative pathological TNM ***:After neo-CRT,the accuracy of TRUS for diagnosing T-staging was 30.9%,with 60.4%(90/149)of cases *** sensitivity of TRUS for T-staging(T0 vs T1 vs T2 vs T3 vs T4)were 16.3%,0%,12.5%,42.6%and 75.0%,*** accuracy of TRUS for diagnosing N-staging after neo-CRT was 81.2%,with the sensitivities of N0 and N+were 93.3%and 31.0%,*** neo-CRT,27.5%(41/149)of patients achieved pathologically complete response(pCR).The sensitivity,specificity,positive predictive value and negative predictive values of TRUS for pCR were 17.1%,99.1%,87.5%and 75.9%,***:TRUS can be applied for restaging T4 and N0,and has potential for screening out patients with pCR in those with locally advanced rectal cancer after neo-CRT,although some stages are overestimated for T-staging and its sensitivity for predicting pCR is low.