“稳定的”视神经疾病患者的迟发性视力减退
Delayed visual decline in patients with “ sta-ble” optic neuropathy作者机构：243 Charles St BostonMA02114United States.Dr
出 版 物：《世界核心医学期刊文摘（眼科学分册）》 (Digest of the World Core Medical Journals:Ophthalmology)
年 卷 期：2005年第1卷第12期
页 面：30-30页
学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学]
主 题：视力减退 视神经疾病 视力丧失 视神经萎缩 年龄相关性 正常衰老 神经节细胞 临床病例资料 组织学研究
摘 要：Background: Histological studies on the human optic nerve have documented decreasing axonal nerve fiber counts with age. In patients with optic atrophy, a nonpathological dropout of ganglion cell axons as part of the normal aging process may become clinically significant. Objective: To describe the occurrence of delayed visual loss in patients with presumably “ stable optic neuropathy. Methods: We reviewed the medical records of 3 patients who experienced slowly progressive visual loss in adulthood after suffering childhood optic nerve injury. Results: All 3 patients had a monophasic illness in childhood that caused bilateral optic atrophy and visual impairment. Following decades of stability, each suffered a gradual, symptomatic visual decline that extended over years. No new ophthalmologic, systemic, or neurologic disorder was found that explained the visual decline in any of these patients. Conclusion: We hypothesize that the late visual decline in these 3 patients resulted from deleterious effects of age-related axonal loss on an already depleted population of neurons.
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