Schwann cell Myc-interacting zinc-finger protein 1 without pox virus and zinc finger： epigenetic implications in a peripheral neuropathy

作     者：David Fuhrmann Hans-Peter Elsaisser 

作者机构：Department of Cytobiology and Cytopathobiology Philipps University of Marburg Marburg Germany 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2018年第13卷第9期

页      面：1534-1537页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by Deutsche Forschungsgemeinschaft(DFG grant EL125/6-1) 

主　　题：Schwann celh differentiation peripheral nerve injury histone methylation epigenetics Mizl 

摘      要：Functionality of adult peripheral nerves essentially relies on differentiation of Schwann cells during post- natal development, as well as fine-tuned re- and transdifferentiation in response to peripheral nerve injury. Epigenetic histone modifications play a major role during the differentiation of embryonic stem cells and diverse organ specific progenitor cells, yet only little is known about the epigenetic regulation of Schwa nn cells. Just recently, Fuhrmann et al. reported how the transcription factor Myc-interacting zinc-finger protein 1 （Mizl） might contribute to Schwann cell differentiation through repression of the histone de- methylase Kdm8. Here, we discuss the potential novel role of Mizl in Schwann cell differentiation and give a short overview about previously reported histone modifications underlying peripheral nerve develop- ment and response to injury.