Management of Hepatitis C Post-liver Transplantation: a Comprehensive Review

作     者：Oscar Mitchell Ahmet Gurakar 

作者机构：Department of Transplant Hepatology Division of Gastroenterology and Hepatology Johns Hopkins University School of MedicineBaltimore MD USA 

出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)

年 卷 期：2015年第3卷第2期

页      面：140-148页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Bristol-Myers Squibb  BMS 

主　　题：Hepatitis C Transplant Directly acting antivirals 

摘      要：Infection with hepatitis C virus (HCV) is a common cause of chronic liver disease,and HCV-related cirrhosis and hepatocellular carcinoma are the leading causes for liver transplantation in the Western *** infection of the transplanted liver allograft is universal in patients with detectable HCV viremia at the time of transplant and can cause a spectrum of disease,ranging from asymptomatic chronic infection to an aggressive fibrosing cholestatic *** HCV is more aggressive in the post-transplant population and is a leading cause of allograft loss,morbidity,and ***,treatment of recurrent HCV has been limited by low rates of treatment success and high side effect *** the past few years,promising new therapies have emerged for the treatment of HCV that have high rates of sustained virological response without the need for interferon based *** addition to being highly effective,these treatments have higher rates of adherence and a lower side effect *** purpose of this review is to summarize current therapies in recurrent HCV infection,to review the recent advances in therapy,and to highlight areas of ongoing research.