Antifertility activity of Artemisia vulgaris leaves on female Wistar rats

作     者：Afsar Shaik Rupesh S Kanhere Rajaram Cuddapah Nelson Kumar S Prasanth Reddy Vara Saisaran Sibyala 

作者机构：Department of PharmacologyP. Rami Reddy Memorial College of Pharmacy 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2014年第12卷第3期

页      面：180-185页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Dr. Ravindra Reddy Principal P. Ramireddy Memorial College of Pharmacy for providing all the necessary assistance required for this study and also his moral support 

主　　题：Antifertility activity Anti-implantation activity Artemisia vulgaris Estrogenic activity 

摘      要：AIM： To evaluate the antifertility activity of Artemisia vulgar＆ leaves on female Wistar rats. METHOD： The plant extract was tested for its effect on implant formation at two dose levels, 300 and 600 *** 1, respectively. The effective methanolic plant extract was further studied for estrogenic potency on ovariectomised immature female Wistar rats. RESULTS： The data presented in this study demonstrate the antifertility potential of Artemisia vulgar＆ methanolic leaf extract, which shows a strong and significant decrease in implant formation （100%）, and a strong estrogenic effect resulting in a significant increase in uterine weight in immature ovariectomised rats. These observations suggest that the methanolic extract of Artemisia vulgaris leaves has strong anti-implantation activity and estrogenic activity. CONCLUSION： The methanolic plant extract ofA. vulgaris has antifertility activity.