Synergistic effects of elevated homocysteine level and abnormal blood lipids on the onset of stroke

作     者：Lu Hao Liming Chen Xiaoyong Sai Zhefeng Liu Guang Yang Rongzeng Yan Lili Wang Caiyun Fu Xuan Xu Zhenzhen Cheng Qiang Wu Shuzhang Li 

作者机构：Chinese PLA General Hospital Institute of Geriatrics Chinese PLA General Hospital Beijing Key Laboratory of Geriatrics 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2013年第8卷第31期

页      面：2923-2931页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by a grant from Medical Science DataSharing Network,Ministry of Science and Technology,China,No.2005DKA32403 Military Medical Scientific Research grants,No.11BJZ32,No.12BJZ271 and No.10BJZ202 

主　　题：neural regeneration stroke cysteine risk factor case-control study abnormal bloodmedication inpatients cardiovascular disease paired analysis grants-supportedneuroregenerationlipidspaper 

摘      要：Hyperhomocysteinemia and abnormal blood lipids are independent risk factors for stroke. However, whether both factors exert a synergistic effect in the onset of stroke remains unclear. The present study is a retrospective analysJs of 2 089 cases of stroke and 2 089 control cases of simple in- tervertebral disk protrusion using a paired multivariate logistic regression method. Adjusting for known confounding variables including the patients＇ age, gender, smoking status, alcohol con- sumption status, patient and family medical history, and clinical biochemical indices, elevated ho- mocysteine level was related to the onset of stroke. Patients with elevated homocysteJne levels and abnormal blood lipids showed a 40.9 % increase in the risk for stroke compared to patients with normal homocysteine levels and blood lipids （odds ratio 1.409; 95% confidence interval 1.127-1.761）. These results indicate that elevated homocysteine and abnormal blood lipids exert synergistic effects in the onset of stroke. Patients with elevated homocysteine levels and abnormal blood lipids are predisposed to stroke.