Improved local control without elective nodal radiotherapy in patients with unresectable NSCLC treated by 3D-CRT

作     者：YANG Kunyu CAO Fengjun WANG Jianhua LIU Li ZHANG Tao WU Gang 

作者机构：Cancer Center of Union HospitalHuazhong University of Science and TechnologyWuhan 430023China Department of OncologyShiyan People’s HospitalShiyan 442000China Department of Radiation OncologyRui’an People’s HospitalRui’an 325200China 

出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)

年 卷 期：2007年第1卷第4期

页      面：381-385页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：carcinoma,non-small-cell lung elective nodal irradiation non-elective nodal irradiation 

摘      要：To investigate the influence of prophylactic elec-tive nodal irradiation on the therapeutic results of definitive radiotherapy for patients with stage IIIA or stage IIIB unre-sectable non-small-cell lung cancer,55 patients with clini-cally inoperable advanced non-small-cell lung cancer were *** four cycles of induction chemotherapy,the patients were divided into two groups at *** one group,the elective nodal irradiation was included in clinical tumor volume(CTV)of definitive radiotherapy(ENI group);and in the other group,elective nodal irradiation was not included in CTV(non-ENI group).For the patients in the ENI group,the mean prescription dose for gross tumor volumes was 58.4 Gy,while for the patients in the non-ENI group,it was 65.8 Gy(P0.05).The responsive rates were 45.8%and 74.0%(P0.05),and the rate of the elective nodal failure(ENF)was 4.2%and 11.1%,***-Meier analysis showed that the mean local-progression-free survival time was 11.0 and 15.0 months,and one-year local-failure rates were 51.9%and 24.5%(P0.05).The median overall survival time was 13.0 and 15.0 months,respectively(P=0.084).The one-year survival rates were 55.7%and 72.5%,and two-year survival rates were 0%and 19.9%.There was no significant difference in the occurrences of radiation-associated complications between the two *** results showed that omitting elective nodal irradiation did not result in a high incidence of elective nodal *** the contrary,it decreased local failure by increasing prescrip-tion doses to the primary diseases and lymphadenopaphy,and thereby it may further prolong the patients’survival.