Preparation and Crystal Structure of 12β,15α-dihydroxyprogesterone

作     者：孙华 沈妍君 赵旭 王敏 

作者机构：Key Laboratory of Industrial MicrobiologyMinistry of EducationCollege of BiotechnologyTianjin University of Science and Technology 

出 版 物：《Chinese Journal of Structural Chemistry》 (结构化学（英文）)

年 卷 期：2011年第30卷第12期

页      面：1687-1690页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by the Natural Science Foundation of Tianjin (Nos. 08JCZDJC15200 and 11JGYBJC14300) the Program for New Century Excellent Talents in University (No. NCET-08-0911) 

主　　题：crystal structure progesterone 12β 15α-dihydroxyprogesterone biotransformation 

摘      要：Progesterone（1） was biotransformed into the title compound 12β,15α-dihydroxy-progesterone（2） with Colletotrichum lini *** biotransformation process was monitored with *** structure of 2 was determined by 1H NMR,13C NMR,ESI-MS and single-crystal X-ray *** crystal of the compound belongs to orthorhombic,space group P212121 with a = 8.0671（9）,b = 12.3970（15）,c = 18.532（3） ,Z = 4,V = 1853.3（4）3,Dc = 1.242 mg/m3,μ = 0.084 mm-1,F（000） = 752,R = 0.0373 and wR = ***-crystal X-ray diffraction analysis reveals that a 1D supramolecular structure of 2 has been constructed by multiply intermolecular O（2）-H（2）…O（4） and O（3）-H（3）…O（2） H-bonding interactions.