Kinases and glutathione transferases:selective and sensitive targeting

作     者：Yasemin G.ISGOR Belgin S.ISGOR 

作者机构：Chemistry GroupFaculty of EngineeringAtilim UniversityAnkara 06836Turkey 

出 版 物：《Frontiers in Biology》 (生物学前沿（英文版）)

年 卷 期：2011年第6卷第2期

页      面：156-169页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：glutathione transferase protein tyrosine kinase small molecule inhibitors c-Src signal transduction drug targeting 

摘      要：Kinases,representing almost 500 proteins in the human genome,are responsible for catalyzing the phosphorylation reaction of amino acid residues at their *** the largest family of kinases,the protein tyrosine kinases(PTKs)have roles in controlling the essential cellular activities,and their deregulation is generally related to pathologic *** recent efforts on identifying their signal transducer or mediator role in cellular signaling revealed the interaction of PTKs with numerous enzymes of different classes,such as Ser/Thr kinases(STKs),glutathione transferases(GSTs),and receptor tyrosine kinases(RTKs).In either regulation or enhancing the signaling,PTKs are determined in close interaction with these enzymes,under specific cellular conditions,such as oxidative stress and *** this concept,intensive research on thiol metabolizing enzymes recently showed their involvement in the physiologic functions in cellular signaling besides their well known traditional role in antioxidant *** shared signaling components between PTK and GST family enzymes will be discussed in depth in this research review to evaluate the results of recent studies important in drug targeting for therapeutic intervention,such as cell viability,migration,differentiation and proliferation.