Alkaline phosphatase flare with hyperostosis of bone metastases in lung adenocarcinoma treated with gefitinib

作     者：Hiroto Kaneko Kazuho Shimura Yosuke Matsumoto Mihoko Yoshida Masafumi Taniwaki Junya Kuroda 

作者机构：Department of HematologyAiseikai Yamashina Hospital19-4 Shichouno-choYamashina-kuKyoto 607-8086Japan Department of HematologyKyoto Prefectural University of Medicine465 Kajii-choKawaramachi HirokojiKamigyou-kuKyoto 602-8566Japan 

出 版 物：《Journal of Cancer Metastasis and Treatment》 (癌症转移与治疗（英文版）)

年 卷 期：2017年第3卷第1期

页      面：34-37页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Alkaline phosphatase bone metastasis hyperostosis gefitinib 

摘      要：Alkaline phosphatase(ALP)flare has been reported to occur during cancer treatment as a favorable event,particularly in the presence of bone *** have been only a few reports in lung cancer and associated radiographic findings have seldom been *** authors observed ALP flare in a female patient with lung adenocarcinoma soon after the initiation of ***,on computed tomography,metastatic lesions of the rib and thoracic spine showed marked hyperostosis,with sizes larger than the original bone structure,suggesting efficacy of *** significance of such hyperostosis should be elucidated.