Targeting Proteins for Degradation by Arabidopsis COP1： Teamwork Is What Matters

作     者：Rongcheng Lin Haiyang Wang 

作者机构：Boyce Thompson Institute for Plant Research Comell University Ithaca NY 14853 USA 

出 版 物：《Journal of Integrative Plant Biology》 (植物学报（英文版）)

年 卷 期：2007年第49卷第1期

页      面：35-42页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071008[理学-发育生物学] 

基　　金：Supported by Boyce Thompson Institute  Triad Foundation and National Science Foundation (MCB-0420932). Publication of this paper is supported by the National Natural Science Foundation of China (30624808) and Science Publication Foundation of the Chinese Academy of Sciences.Acknowledgements We thank Dr Xing-Wang Deng(Yale University) and Dr Ute Hoecker(University of Düsseldorf Germany) for helpful discussion.We also thank Blackwell Publishing and Dr Ute Hoecker for allowing us to use the modified figures (Figures 2 4) in this review 

主　　题：Arabidopsis COP1 E3 ligase photomorphogenesis proteolysis SPA 

摘      要：Arsbidopsis COP1 （Constitutive Photomorphogenic 1） defines a key repressor of photomorphogenesis in darkness by acting as an E3 ubiquitin Iigase in the nucleus, and is responsible for the targeted degradation of a number of photomorphogenesis-promoting factors, including phyA, HY5, LAF1, and HFR1. Light activation of multiple classes of photoreceptors （including both phytochromes and cryptochromes） inactivates COP1 and reduces its nuclear abundance, allowing the accumulation of these positively acting light signaling intermediates to promote photomorphogenic development. Recent studies suggest that Arabidopsis COP1 teams up with a family of SPA proteins （SPA1-SPA4） to form the physiologically active COP1-SPA E3 ubiquitin ligase complexes. These COP1-SPA complexes play overlapping and distinct functions in regulating seedling photomorphogenesis under different light conditions and adult plant growth. Further, the COP1-SPA complexes act In concert at a biochemical level with the CDD （COP10, DET1, and DDB1） complex and COP9 signalosome （CSN） to orchestrate the repression of photomorphogenesis.