Leptin signaling and leptin resistance

作     者：Yingjiang Zhou Liangyou Rui 

作者机构：Cambridge LaboratoriesPfizer Worldwide Research&DevelopmentCambridgeMA 02139USA Department of Molecular and Integrative PhysiologyUniversity of Michigan Medical SchoolAnn ArborMI 48109USA 

出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)

年 卷 期：2013年第7卷第2期

页      面：207-222页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：National Institute of Diabetes and Digestive and Kidney Diseases  NIDDK  (R01DK091591) 

主　　题：leptin signaling leptin receptor energy balance leptin resistance obesity 

摘      要：Leptin is secreted into the bloodstream by adipocytes and is required for the maintenance of energy homeostasis and body *** deficiency or genetic defects in the components of the leptin signaling pathways cause *** controls energy balance and body weight mainly through leptin receptor b(LEPRb)-expressing neurons in the brain,particularly in the *** LEPRb-expressing neurons function as the first-order neurons that project to the second-order neurons located within and outside the hypothalamus,forming a neural network that controls the energy homeostasis and body *** factors,including inflammation and endoplasmic reticulum(ER)stress,contribute to leptin *** resistance is the key risk factor for *** review is focused on recent advance about leptin action,leptin signaling,and leptin resistance.