Screening for Y chromosome microdeletions in idiopathic and nonidiopathic infertile men with varicocele and cryptorchidism
Screening for Y chromosome microdeletions in idiopathic and nonidiopathic infertile men with varicocele and cryptorchidism作者机构：Department of Urology First Affiliated Hospital Nanjing Medical University Nanjing 210029 China Key Laboratory of Reproductive Medicine of Jiangsu Province Nanjing Medical University Nanjing 210029 China Model Animal Research Center Nanjing University Nanjing 210032 China
出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)
年 卷 期：2005年第118卷第17期
页 面：1462-1467页
核心收录：
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
基 金：The work was supported by the "135" Foundation of JiangsuProvince (No.0151)
主 题：Y chromosome microdeletions multiplex polymerase chain reaction male infertility
摘 要：Cytogenetic and molecular studies of azoospermic and oligozoospermic males have suggested the presence of azoospermia factors （AZF） in the Y chromosome. Deletion in AZF regions has been reported to disrupt spermatogenesis and cause infertility. Several candidate genes responsible for spermatogenesis have been identified in this region and some of them are thought to be functional in human spermatogenesis. And we reported clinical and molecular studies of Y chromosome microdeletions in Chinese. This study aimed at assessing the frequency of microdeletions in Chinese men with idiopathic and nonidiopathic infertility problems and dicussing the clinical significance of the AZF region.
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