Coordination-responsive drug release inside gold nanorod @ metal-organic framework core-shell nanostructures for near-infrared-induced synergistic chemo-photothermal therapy

作     者：Yantao Li Jun Jin Dawei Wang Jiawei Lv Ke Hou Yaling Liu Chunying Chen Zhiyong Tang 

作者机构：CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2018年第11卷第6期

页      面：3294-3305页

核心收录：

学科分类：080503[工学-材料加工工程] 0808[工学-电气工程] 0809[工学-电子科学与技术（可授工学、理学学位）] 08[工学] 0804[工学-仪器科学与技术] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 

基　　金：supported financially by National Basic Research Program of China National Natural Science Foundation for Distinguished Youth Scholars of China 国家自然科学基金 Frontier Science Key Project of the Chinese Academy of Sciences CAS-CSIRO Cooperative Research Program "Strategic Priority Research Program" of Chinese Academy of Sciences Youth Innovation Promotion Association of Chinese Academy of Sciences (Y. L. L.) K. C. Wong Education Foundation (Z. Y. T.) 

主　　题：core-shell nanostructures coordination bonds dual stimuli response synergistic cancer therapy 

摘      要：Multifunctional core-shell nanostructures formed by integration of distinct components have received wide attention as promising biological platforms in recent years. In this work, crystalline zeolitic imidazolate framework-8 （ZIF-8）, a typical metal-organic framework （MOF）, is coated onto single gold nanorod （AuNR） core for successful realization of synergistic photothermal and chemotherapy triggered by near-infrared （NIR） light. Impressivel）~ high doxorubicin hydrochloride （DOX） loading capacity followed by pH and NIR light dual stimuli-responsive DOX release can be easily implemented through formation and breakage of coordination bonds in the system. Moreover, under NIR laser irradiation at 808 nm, these novel AuNR@MOF core-shell nanostructures exhibit effective synergistic chemo-photothermal therapy both in vitro and in vivo, confirmed by cell treatment and tumor ablation via intravenous injection.