Relationship of ultrasonic elastography parameters of cervical cancer with the cancer cell growth and angiogenesis in the lesion tissue

作     者：Bing-Yan Lai 

作者机构：B-Ultrasound RoomShaanxi Provincial Hospital of Traditional Chinese MedicineXi'an CityShaanxi Province710002 

出 版 物：《Journal of Hainan Medical University》 (海南医学院学报（英文版）)

年 卷 期：2017年第23卷第20期

页      面：97-100页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Natural Science Basic Research Project of Shaanxi Province No:2012JN4039 

主　　题：Cervical cancer Ultrasonic elastography parameter Proliferation gene Apoptosis gene Angiogenesis-related gene 

摘      要：Objective: To study the relationship of ultrasonic elastography parameters of cervical cancer with the cancer cell growth and angiogenesis in the lesion tissue. Methods: A total of 110 patients who were diagnosed with cervical cancer in the hospital between December 2015 and January 2017 were collected as the observation group, 80 patients who received hysteroscopic cervical polyp resection in the hospital during the same period were collected as the control group. The levels of cervical ultrasonic elastography parameters in the two groups were detected, and fluorescence quantitative PCR was used to determine the expression of proliferation genes, apoptosis genes and angiogenesis-related genes in the lesion tissue. Pearson test was used to evaluate the correlation between cervical ultrasonic elastography parameters and the tumor malignancy indexes. Results: Elastic image press release index and strain ratio of local lesion of observation group were significantly higher than those of control group;GBP1 mRNA expression in lesion tissue of observation group was lower than that in lesion tissue of control group while Prdx4, STAT3 and Sp2 mRNA expression were higher than those in lesion tissue of control group;Survivin, FasL and Bcl-2 mRNA expression in lesion tissue of observation group were higher than those in lesion tissue of control group while Fas and Bax mRNA expression were lower than those in lesion tissue of control group;VEGF, MMP-9, COX-2 and HIF-1 mRNA in lesion tissue of observation group were significantly higher than those in lesion tissue of control group. Conclusion: Elastic image press release index and strain ratio of cervical tissue of patients with cervical cancer are higher, and the specific increase is directly correlated with the tumor malignancy.