Assessment of autonomic function in untreated adult coeliac disease

作     者：Gian Marco Giorgetti Antonio Tursi Cesare Iani Fiavio Areiprete Giovanni Brandimarte Ambrogio Capria Luigi Fontana 

作者机构：Department of Internal MedicineClinical Nutrition Unit"S.Eugenio" HospitalRomeItaly Digestive Endoscopy Unit"Lorenzo Bonomo"HospitalAndria (BA)Italy Division of Neurology"S.Eugenio"HospitalRomeItaly Department of Internal MedicineDivision of Gastroenterology"Cristo Re" HospitalRomeItaly Department of Internal Medicine and Immunology"Tor Vergata" UniversityRomeItaly 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2004年第10卷第18期

页      面：2715-2718页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Adult Aged Autonomic Nervous System Diseases Blood Pressure Celiac Disease Female Gluten dosage Heart Rate Humans Hypotension, Orthostatic Male Middle Aged 

摘      要：AIM: Some recent studies showed that alteration of upper-gut motility in coeliac disease may be related to dysfunction of autonomic nervous system. The aim of our study was to investigate whether autonomic nervous system was altered in untreated and unselected coeliac disease ***: We studied 8 untreated and consecutive coeliac disease patients (2 males and 6 females, age range 37±14.5 years). Histological evaluation of duodenal mucosa, anti-gliadin antibodies (AGA), antiendomysial antibodies (EMA) and anti-tTG antibodies and sorbitol H2 breath test were performed in all patients. Extrinsic autonomic neuropathy was assessed by the standardized measurement of cardiovascular reflexes (lying-to-standing,Valsalva manoeuvre, deep breathing, sustained handgrip).The results obtained were compared with a healthy,asymptomatic control group (6 males and 7females, age range 42.3±13.5 years).RESULTS: Coeliac patients exhibited a lower increase of PAS as a response to isometric effort, a reduction of spectral power LF as a response to clinostatic position,but without statistical significance. Also they showed a lower tolerance to orthostatic position, associated with a latent disequilibrium of sympathetic-vagal balance, a relative prevalence of parasympathetic component of the autonomic function. However, these results were not statistically significant when compared with control group(P = n.s.). And they were unchanged after 6 and 12 mo of gluten-free ***: This study failed to confirm a significant correlation between autonomic dysfunction and coeliac disease, yet we could not exclude a role of autonomic dysfunction in the genesis of systemic symptoms in some coeliacs.