Wernicke encephalopathy in children and adolescents

作     者：Matt Lallas Jay Desai 

作者机构：Division of NeurologyChildren's Hospital Los AngelesCaliforniaUSA Keck School of Medicine of University of Southern CaliforniaCaliforniaUSA 

出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)

年 卷 期：2014年第10卷第4期

页      面：293-298页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：Funding:The authors report receipt of no financial support for the research and/or authorship of this article 

主　　题：ataxia ophthalmoplegia thiamine vitamin B1 Wernicke encephalopathy 

摘      要：Background:Wernicke encephalopathy is caused by thiamine(vitamin B1)defi *** is generally considered to be a disease of adult ***,it is known to occur in the pediatric population and in non-alcoholic *** sources:We searched PubMed with the key words Wernicke,thiamine,pediatric,children and adolescents and selected publications that were deemed ***:The global prevalence rates of hunger,poverty and resultant nutrient deprivation have decreased in the 21st ***,several scenarios which may predispose to Wernicke encephalopathy may be increasingly prevalent in children and adolescents such as malignancies,intensive care unit stays and surgical procedures for the treatment of *** predisposing conditions include magnesium defi ciency and defects in the SLC19A3 gene causing thiamine transporter-2 *** classic triad consists of encephalopathy,oculomotor dysfunction and gait ataxia but is not seen in a majority of *** should be instituted immediately when the diagnosis is suspected clinically without waiting for laboratory confi *** magnetic resonance findings include symmetric T2 hyperintensities in dorsal medial thalamus,mammillary bodies,periaqueductal gray matter,and tectal ***:Wernicke encephalopathy is a medical *** in its recognition and treatment may lead to significant morbidity,irreversible neurological damage or even *** article aims to raise the awareness of this condition among pediatricians.