Cancer immunotherapy: a brief review of the history, possibilities, and challenges ahead
Cancer immunotherapy:a brief review of the history,possibilities,and challenges ahead作者机构：Department of PathologyAmerican University of the Caribbean School of MedicineCupecoySt.MaartenNetherlands Antilles.
出 版 物：《Journal of Cancer Metastasis and Treatment》 (癌症转移与治疗（英文版）)
年 卷 期：2017年第3卷第1期
页 面：250-261页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Cancer immunotherapy immune checkpoint inhibitors PD-1 programmed death-ligand 1 cytotoxic T-lymphocyte-associated antigen-4 adoptive cell therapy cancer vaccines oncolytic viruses history of cancer immunology
摘 要：The knowledge that the body possesses natural defenses to combat cancer existed long before the modern period,with multiple anecdotal reports of tumors miraculously disappearing,sometimes spontaneously or after a febrile or infectious *** tumor regression of untreated malignant tumors is currently a well-accepted albeit rare phenomenon,and it is recognized that immunosuppression is associated with a higher cancer *** treatment of bladder carcinoma by intravesical administration of live attenuated Bacillus Calmette-Guérin bacteria was shown to be very effective in 1976 and is now standard *** immunity against cancer involves complex interactions between the tumor,the host,and the *** immunotherapy uses various strategies to augment tumor immunity and represents a paradigm shift in treating cancer,since attention has become more focused on the“biologic passportof the individual tumor rather than the site of origin of the *** different types of cancer immunotherapies discussed here include biologic modifiers,such as cytokines and vaccines,adoptive cell therapies,oncolytic viruses,and antibodies against immune checkpoint inhibitors,such as the co-inhibitory T-cell receptor PD-1 and one of its ligands,programmed death-ligand 1.
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