Targeting glioma stem cells via the Hedgehog signaling pathway

作     者：Yang Liu Xing Liu Ling‑Chao Chen Wen‑Zhong Du Yu‑Qiong Cui Xing‑Yin Piao Yong‑Li Li Chuan‑Lu Jiang 

作者机构：Department of NeurosurgeryThe Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086HeilongjiangChina 

出 版 物：《Neuroimmunology and Neuroinflammation》 (神经免疫与神经炎症（英文版）)

年 卷 期：2014年第1卷第1期

页      面：51-59页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This project was supported by the National High Technology Research and Development Program 863(2012AA02A508) national 11th 5 years supporting project(2007BA105B08) Heilongjiang Natural Science key projects(C03030307) 

主　　题：Cancer stem cells glioma Hedgehog microRNA 

摘      要：Cancer is one of the leading causes of death *** are among the most devastating tumor types,and current clinical therapies are *** reports revealed the importance of glioma-propagating cells in the malignancy of *** cells,also referred to as glioma stem cells(GSCs),share similarities with neural stem cells(NSCs).The Hedgehog(Hh)signaling pathway controls tissue polarity,patterning maintenance,and maintenance of NSCs during embryonic *** activation of the Hh pathway resulting from mutation and deregulation has recently been recognized to cause tumorigenesis in a wide variety of tissues,including gliomas and *** this review,we explore the role of the Hh signaling pathway in GSCs and its potential as a therapeutic strategy.