miR-34a: Multiple Opposing Targets and One Destiny in Hepatocellular Carcinoma
miR-34a: Multiple Opposing Targets and One Destiny in Hepatocellular Carcinoma作者机构：Pharmaceutical Biology Department Faculty of Pharmacy and Biotechnology German University in Cairo Cairo Egypt pharmacology and Toxicology Department Faculty of Pharmacy and Biotechnology German University in Cairo Cairo Egypt Department of General Surgery Faculty of Medicine Cairo University Cairo Egypt Virology and Immunology Cancer Biology Department National Cancer Institute Cairo University Cairo Egypt Department of Endemic Medicine and HepatologyCairo University Cairo Egypt pharmacology and Toxicology Department Faculty of Pharmacy and Biotechnology German University in Cairo Cairo Egypt School of Medicine New Giza University Cairo Egypt
出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)
年 卷 期：2016年第4卷第4期
页 面：300-305页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：MicroRNA Hepatocellular carcinoma Apoptosis PCR array.
摘 要：Background and Aims:The role of miR-34a in hepatocellular carcinoma (HCC) is controversial and several unresolved issues remain,including its expression pattern and relevance to tumor etiology,tumor stage and prognosis,and finally,its impact on ***:miR-34a expression was assessed in hepatitis C virus (HCV)-induced non-metastatic HCC tissues by ***-7 cells were transfected with miR-34a mimics and the impact of miR-34a was examined on 84 pro-apoptotic/anti-apoptotic genes using PCR array;its net effect was tested on cell viability via ***:miR-34a expression was up-regulated in HCC ***,miR-34a induced a large set of pro-apoptotic/anti-apoptotic genes,with a net result of triggering apoptosis and repressing cell ***:HCC-related differential expression of miR-34a could be etiology-based or stage-specific,and low expression of miR-34a may predict poor *** study s findings also emphasize the role of miR-34a in apoptosis.
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