Therapeutic potential and challenges of targeting sirtuins in neurodegenerative diseases

作     者：Li GAN 

作者机构：Gladstone Institute of Neurological Disease and Department of NeurologyUniversity of CaliforniaSan Francisco 94158USA 

出 版 物：《Frontiers in Biology》 (生物学前沿（英文版）)

年 卷 期：2010年第5卷第4期

页      面：324-330页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Sirtuins aging neurodegenerative disease 

摘      要：Aging is the predominant risk factor for major neurodegenerative *** underlying mechanisms are largely *** of the sirtuin family of protein deacetylases support and promote longevity in diverse organisms and can extend lifespan when *** are involved in fundamental mechanisms in age-related neurodegenerative diseases,including protein aggregation and homeostasis,survival and stress responses,and inflammatory *** this review,we will discuss the neurobiology of sirtuins and their multifaceted roles in the pathogenesis of neurodegenerative *** will also examine the potential and challenges of targeting sirtuin pathways to treat these devastating conditions.