A combination of the leaves and tuber of Icacina senegalensis ***(Icacinaceae)improves the antimalarial activity of the plant in mice

作     者：Esien David-Oku Juliet Ifeoma Obiajunwa-Otteh 

作者机构：Biochemistry DepartmentFaculty of Basic Medical SciencesUniversity of CalabarCalabarNigeria 

出 版 物：《Journal of Coastal Life Medicine》 (海岸生命医学杂志（英文版）)

年 卷 期：2015年第10期

页      面：821-825页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Icacina senegalensis tuber Antimalaria Mice Plasmodium berghei Chemosuppression Curative 

摘      要：Objective:To investigate the possibility of increased antimalarial activity of Icacina senegalensis ***(Icacinaceae)upon a combination of its leaves and tubers against Plasmodium berghei malaria in ***:Chloroquine sensitive ANKA clones of Plasmodium berghei were used to develop experimental models based on intraperitoneal injection of 10^(7)parasitized erythrocytes in phosphate buffer saline(pH 7.2)and subsequent development of *** models were employed to investigate prophylactic and curative anti-malarial activities of tuber and tuberleaf methanol extracts of the plant at selected dosages(25,50 and 100 mg/kg body weight).Chloroquine with a curative dosage of 10 mg/kg body weight was used as positive control in both ***:Tuber and tuber-leaf extracts produced a dose-dependent chemosuppression of the parasites,with higher activity and mean survival time exhibited by the combined ***:Anti-plasmodia activity has been discovered in methanol extract of Icacina senegalensis tuber *** observed optimization of the antimalarial actions of the plant upon a combination of its leaf and tuber opens a new area of medicinal plant research.