Statistical properties of nucleotide clusters in DNA sequences

作     者：成军 章林溪 

作者机构：Department of Physics Jinhua University Jinhua 321017 China Department of Physics Zhejiang University Hangzhou 310027 China 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2005年第6卷第5期

页      面：408-412页

核心收录：

学科分类：0710[理学-生物学] 0810[工学-信息与通信工程] 07[理学] 0805[工学-材料科学与工程（可授工学、理学学位）] 071007[理学-遗传学] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

基　　金：Project supported by the National Natural Science Foundation ofChina (Nos. 20174036 20274040) and the Natural Science Founda-tion of Zhejiang Province (Nos. R404047 10102) China 

主　　题：DNA sequence Plasmodium falciparum 3D7 Nucleotide clusters Power law 

摘      要：Using the complete genome of Plasmodium falciparum 3D7 which has 14 chromosomes as an example, we have examined the distribution functions for the amount of C or G and A or T consecutively and non-overlapping blocks of m bases in this system. The function P(S) about the number of the consecutive C-G or A-T content cluster conforms to the relation P(S)∝e? ; αs values of the scaling exponent αCG are much larger than αAT; and αAT of 14 chromosomes are hardly changed, whereas αCG of 14 chromosomes have a number of fluctuations. We found maximum value of A-T cluster size is much larger than C-G, which implies the existence of large A-T cluster. Our study of the width function ξ(m) of cluster C-G content showed that follows good power law ξ(m)∝m?γ. The average γ for 14 chromosomes is 0.931. These investigations provide some insight into the nucleotide clusters of DNA sequences, and help us understand other properties of DNA sequences.