Gastro-protective effect of Ziziphus abyssinica root extracts in ethanol-induced acute ulcer in Wistar rats

作     者：Salahuddin Yau Mansura Abimbola Abdulazeez Kola Mathew Anigo Auwalu Garba 

作者机构：Department of BiochemistryAhmadu Bello UniversityZariaNigeria Centre for Biotechnology ResearchBayero UniversityKanoNigeria 

出 版 物：《Journal of Acute Disease》 (急性病杂志（英文版）)

年 卷 期：2017年第6卷第2期

页      面：62-65页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Ziziphus abyssinica Induced ulcer Gastro-protection Rats 

摘      要：Objective: To evaluate the gastro-protective effect of the aqueous, methanol and hexane root extracts of Ziziphusabyssinica on ethanol induced gastric ulcer in Wistar rats as models. Methods: Seventy rats were divided into seven groups of ten rats each: control group, ulcer control group, standard control group (cimetidine 100 mg/kg body weight), aqueous, methanol, ethyl acetate and hexane extract groups. They were administered the extracts at 300 and 600 mg/kg for two weeks before ulcer was induced, and the protective effect of all extracts determined. Results:Histological changes in gastric tissue were evaluated. Pretreatment withZiziphus abyssinica extracts showed significant (P 0.05) gastro-protective effect with aqueous extract having the highest gastro-protective effect (95% and 93% at 300 and 600 mg/kg extract respectively). Methanol extract had 66.6% and 65.5% protection at 300 and 600 mg/kg respectively. The percentage protection in ethyl acetate extract treated group was 51% and 45% respectively. The group treated with hexane had 23.8% and 28.6% protection at 300 and 600 mg/kg, respectively. Histological study showed that pretreatment with aqueous extract resulted in the preservation of the functional cyto-architecture of the entire mucosa with little pathological changes, compared to other extracts. Conclusions:The results of this study indicated that aqueous extract is effective against induced gastric ulcer.