NADPH oxidase and reactive oxygen species as signaling molecules in carcinogenesis

作     者：Gang WANG 

作者机构：Division of NeurobiologyDepartment of Neurology and NeuroscienceWeill Cornell Medical CollegeCornell UniversityNew YorkNY 10021USA 

出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)

年 卷 期：2009年第3卷第1期

页      面：1-7页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：free radicals tumor phox cell proliferation cancer therapy 

摘      要：Reactive oxygen species(ROS)are small molecule metabolites of oxygen that are prone to participate in redox reactions via their high *** ROS could be generated in reduced nicotina-mide-adenine dinucleotidephosphate(NADPH)oxidase-dependent and/or NADPH oxidase-independent ***,ROS are involved in many signaling cascades that contribute to normal *** classical example is that ROS derived from the NADPH oxidase and released in neurotrophils are able to digest invading *** ROS,however,contribute to patho-genesis of various human diseases including cancer,aging,dimentia and *** signaling messengers,ROS are able to oxidize many targets such as DNA,proteins and lipids,which may be linked with tumor growth,invasion or *** present review summarizes recent advances in our comprehensive understanding of ROS-linked signaling pathways in regulation of tumor growth,invasion and metastasis,and focuses on the role of the NADPH oxidase-derived ROS in cancer pathogenesis.