The role of surfactant and non-invasive mechanical ventilation in early management of respiratory distress syndrome in premature infants
The role of surfactant and non-invasive mechanical ventilation in early management of respiratory distress syndrome in premature infants作者机构：Department of PediatricsDivision of NeonatologyCase Western Reserve University School of MedicineMetroHealth Medical CenterClevelandOhio 44109USA
出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)
年 卷 期：2014年第10卷第3期
页 面：204-210页
核心收录：
学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
基 金：Funding:There are no financial disclosures or disclaimers related to this manuscript
主 题：non-invasive mechanical ventilation prematurity respiratory distress syndrome
摘 要：Background:Surfactant replacement therapy has been used for few decades for the treatment of respiratory distress syndrome(RDS)and has significantly improved morbidity and mortality in premature ***-invasive respiratory support has recently emerged as a strategy in the early management of *** this review,we discuss the different strategies of early management of *** sources:A literature search of PubMed database was conducted to review the *** quality of evidence of key clinical studies was graded according to a modified grading system of the international GRADE ***:Continuous positive airway pressure(CPAP)with selective surfactant is a safe alternative to routine intubation,surfactant and mechanical ventilation in preterm infants with spontaneous breathing,and such an approach has been associated with decreased risk of death and bronchopulmonary *** is a risk of pneumothorax when using a high pressure of CPAP(≥8 cm of H_(2)O),a high partial pressure of carbon dioxide(PCO_(2)75 mm of Hg),and a high fraction of inspired oxygen(FiO_(2)0.6)as a threshold for intubation while on ***:Not all preterm infants need surfactant treatment,and non-invasive respiratory support is a safe and effective approach.
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