Measurement of bone alkaline phosphatase and relative study with osteosarcoma

作     者：YANG Zhiping HUO Yanqing SUN Guangzhi LI Jianmin LI Xin 

作者机构：Orthopaedic DepartmentQilu Hospital of Shandong UniversityJinan 250012China Orthopaedic DepartmentSecond Hospital of Shandong UniversityJinan 250033China Orthopaedic DepartmentThe Fourth People Hospital of JinanJinan 250031China 

出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)

年 卷 期：2007年第1卷第1期

页      面：54-57页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This topic is supported by the Shandong Province Health Department Youth Fund(No.9410) 

主　　题：osteosarcoma alkaline phosphatase 

摘      要：The objective of this paper is to explore the value of bone alkaline phosphatase(BALP)for diagnosing osteosarcoma,evaluating the effect of the chemotherapy,judging the prognosis and supervising the relapse and *** immunoassay was used to check the BALP of the blood serum that was from 42 primary osteosarcoma *** phosphatase(ALP)in blood serum was checked with auto biochemistry *** biopsy tissue and the lesion resected in operation were treated with pathology and histological response was *** patients were followed up from five months to 49 months with an average of 24.3 *** cases relapsed and transferred,among which,16 of them were dead,and others were survival to the end of the *** was more sensitive than ALP in diagnosing osteosarcoma(P=0.015).Fifteen cases decreased to normal value in ALP after preoperative chemotherapy,and 34 cases decreased in *** ALP and BALP in all cases decreased to normal value in *** was significant difference in positive correlation between the decrease of BALP and the increase of histological response(P=0.001,r=0.642).In the followup,there was significant difference in BALP between the group of relapse and transfer and the group of free disease survival(P=0.000).As a check marker in blood serum,BALP,reflecting the process of ossification,has a higher sensitivity than *** has applied value in the diagnosis of osteosarcoma,reflection of the effect of chemotherapy and forecast the prognosis.