Microscopic hyperspectral imaging studies of normal and diabetic retina of rats

作     者：LI QingLi XUE YongQi ZHANG JingFa XIAO GongHai 

作者机构：School of Information ScienceEast China Normal UniversityShanghai 200241China Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200081China School of MedicineShanghai JiaoTong UniversityShanghai 200025China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2008年第51卷第9期

页      面：789-794页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100212[医学-眼科学] 10[医学] 

主　　题：diabetic retinopathy retina microscopic hyperspectral imager spectrum 

摘      要：A microscopic hyperspectral imager was developed based on the microscopic technology and the spectral imaging technology. Some microscopic hyperspectral images of retina sections of the normal, the diabetic, and the treated rats were collected by the new imager. Single-band images and pseudo-color images of each group were obtained and the typical transmittance spectrums were ex-tracted. The results showed that the transmittance of outer nuclear layer cells of the diabetic group was generally higher than that of the normal. A small absorption peak appeared near the 180th band in the spectrum of the diabetic group and this peak weakened or disappeared in the spectrum of the treated group. Our findings indicate that the microscopic hyperspectral images include wealthy information of retina sections which is helpful for the ophthalmologist to reveal the pathogenesis of diabetic reti-nopathy and explore the therapeutic effect of drugs.